Tetrodotoxin (TTX) as a Therapeutic Agent for Pain
Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels (VGSCs).VGSCs play a critical role in neuronal function under both physiological and pathological conditions.TTX has been extensively used to functionally characterize VGSCs, which can be classified as TTX-sensitive or TTX-resistant channels according to their sensi